Investigating the Cytosolic Delivery of Proteins by Lipid Nanoparticles Using the Chloroalkane Penetration Assay. J. Wang, S. Zhang, Y. Li, Q. Xu & J.A. Kritzer. Biochemistry (2024). DOI
Harnessing non-Watson-Crick’s base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells. S. Gao, H. Guan, H. Bloomer, D. Wich, D. Song, J. Khirallah, Z. Ye, Y. Zhao, M. Chen, C. Xu, L. Liu & Q. Xu. Proc Natl Acad Sci U S A 121, e2308415120 (2024). DOI
Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants. Z. Ye, S.R. Bonam, L.G.A. McKay, J.A. Plante, J. Walker, Y. Zhao, C. Huang, J. Chen, C. Xu, Y. Li, L. Liu, J. Harmon, S. Gao, D. Song, Z. Zhang, K.S. Plante, A. Griffiths, J. Chen, H. Hu & Q. Xu. Proc Natl Acad Sci U S A 120, e2311752120 (2023). DOI
Nanomechanical action opens endo-lysosomal compartments. Y. Zhao, Z. Ye, D. Song, D. Wich, S. Gao, J. Khirallah & Q. Xu. Nat Commun 14, 6645 (2023). DOI
A high-throughput approach of screening nanoparticles for targeted delivery of mRNA. J. Khirallah & Q. Xu. Cell Rep Methods 3, 100572 (2023). DOI
The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of Vaccinology. Z. Ye, J. Harmon, W. Ni, Y. Li, D. Wich & Q. Xu. ACS Nano 17, 15231-15253 (2023). DOI
Gemini Amphiphiles: Robust Cytosolic Delivery of Therapeutic Biomacromolecules through Non-Endocytic Translocation Pathways. Y. Zhao, D. Wich & Q. Xu. ACS Cent Sci 9, 1266-1268 (2023). DOI
A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Z.A. Ely, N. Mathey-Andrews, S. Naranjo, S.I. Gould, K.L. Mercer, G.A. Newby, C.M. Cabana, W.M. Rideout, 3rd, G.C. Jaramillo, J.M. Khirallah, K. Holland, P.B. Randolph, W.A. Freed-Pastor, J.R. Davis, Z. Kulstad, P.M.K. Westcott, L. Lin, A.V. Anzalone, B.L. Horton, N.B. Pattada, S.L. Shanahan, Z. Ye, S. Spranger, Q. Xu, F.J. Sanchez-Rivera, D.R. Liu & T. Jacks. Nat Biotechnol 42, 424-436 (2023). DOI
A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta. B. Carter, P. Huang, G. Liu, Y. Liang, P.J.C. Lin, B.H. Peng, L.G.A. McKay, A. Dimitrakakis, J. Hsu, V. Tat, P. Saenkham-Huntsinger, J. Chen, C. Kaseke, G.D. Gaiha, Q. Xu, A. Griffiths, Y.K. Tam, C.K. Tseng & D.K. Gifford. Front Immunol 14, 1135815 (2023). DOI
Clinical progress in genome-editing technology and in vivo delivery techniques. J. Khirallah, M. Eimbinder, Y. Li & Q. Xu. Trends Genet 39, 208-216 (2023). DOI
Lipidoid Artificial Compartments for Bidirectional Regulation of Enzyme Activity through Nanomechanical Action. Y. Zhao, S. Gao, D. Song, Z. Ye, R. Xu, Y. Luo & Q. Xu. J Am Chem Soc 145, 551-559 (2022). DOI
Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8(+) T cell response. J. Chen, Z. Ye, C. Huang, M. Qiu, D. Song, Y. Li & Q. Xu. Proc Natl Acad Sci U S A 119, e2207841119 (2022). DOI
Engineering a Nano/Biointerface for Cell and Organ-Selective Drug Delivery. D. Song & Q. Xu. Langmuir 38, 9092-9098 (2022). DOI
The effects of protein corona on in vivo fate of nanocarriers. Q. Xiao, M. Zoulikha, M. Qiu, C. Teng, C. Lin, X. Li, M.A. Sallam, Q. Xu & W. He. Adv Drug Deliv Rev 186, 114356 (2022). DOI
Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs. Y. Li, Z. Ye, H. Yang & Q. Xu. Acta Pharm Sin B 12, 2624-2639 (2022). DOI
Current Developments and Challenges of mRNA Vaccines. J. Chen, J. Chen & Q. Xu. Annu Rev Biomed Eng 24, 85-109 (2022). DOI
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. M. Qiu, Y. Tang, J. Chen, R. Muriph, Z. Ye, C. Huang, J. Evans, E.P. Henske & Q. Xu. Proc Natl Acad Sci U S A 119(2022). DOI
Challenges in delivering therapeutic peptides and proteins: A silk-based solution. J. Wu, J.K. Sahoo, Y. Li, Q. Xu & D.L. Kaplan. J Control Release 345, 176-189 (2022). DOI
In Vitro Engineering Chimeric Antigen Receptor Macrophages and T Cells by Lipid Nanoparticle-Mediated mRNA Delivery. Z. Ye, J. Chen, X. Zhao, Y. Li, J. Harmon, C. Huang, J. Chen & Q. Xu. ACS Biomater Sci Eng 8, 722-733 (2022). DOI
CRISPR/Cas9 ribonucleoprotein-mediated genome and epigenome editing in mammalian cells. H. Bloomer, J. Khirallah, Y. Li & Q. Xu. Adv Drug Deliv Rev 181, 114087 (2022). DOI
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference. R.L. Hershman, Y. Li, F. Ma, Q. Xu & J.A. Van Deventer. ChemMedChem 17(2022). DOI
Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing. M. Qiu, Y. Li, H. Bloomer & Q. Xu. Acc Chem Res 54, 4001-4011 (2021). DOI
Osteogenic effects of microRNA-335-5p/lipidoid nanoparticles coated on titanium surface. Q. Wang, X. Wang, P. Valverde, D. Murray, M.M. Dard, T. Van Dyke, Q. Xu, X. Xu, N. Karimbux, Q. Tu & J. Chen. Archives of Oral Biology 129, 105207 (2021). DOI
Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy. T.-C. Ho, H.S. Kim, Y. Chen, Y. Li, M.W. Lamere, C. Chen, H. Wang, J. Gong, C.D. Palumbo, J.M. Ashton, H.-W. Kim, Q. Xu, M.W. Becker & K.W. Leong. Science Advances 7, eabg3217 (2021). DOI
In situ cancer vaccination using lipidoid nanoparticles. J. Chen, M. Qiu, Z. Ye, T. Nyalile, Y. Li, Z. Glass, X. Zhao, L. Yang, J. Chen & Q. Xu. Science Advances 7(2021). DOI
Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice. C. Brandon, C. Jinjin, K. Clarety, D. Alexander, D.G. Gaurav, X. Qiaobing & K.G. David. bioRxiv, 2021.2005.2002.442052 (2021). DOI
The NIH Somatic Cell Genome Editing program. K. Saha, E.J. Sontheimer, P.J. Brooks, M.R. Dwinell, C.A. Gersbach, D.R. Liu, S.A. Murray, S.Q. Tsai, R.C. Wilson, D.G. Anderson, A. Asokan, J.F. Banfield, K.S. Bankiewicz, G. Bao, J.W.M. Bulte, N. Bursac, J.M. Campbell, D.F. Carlson, E.L. Chaikof, Z.-Y. Chen, R.H. Cheng, K.J. Clark, D.T. Curiel, J.E. Dahlman, B.E. Deverman, M.E. Dickinson, J.A. Doudna, S.C. Ekker, M.E. Emborg, G. Feng, B.S. Freedman, D.M. Gamm, G. Gao, I.C. Ghiran, P.M. Glazer, S. Gong, J.D. Heaney, J.D. Hennebold, J.T. Hinson, A. Khvorova, S. Kiani, W.R. Lagor, K.S. Lam, K.W. Leong, J.E. Levine, J.A. Lewis, C.M. Lutz, D.H. Ly, S. Maragh, P.B. McCray, T.C. McDevitt, O. Mirochnitchenko, R. Morizane, N. Murthy, R.S. Prather, J.A. Ronald, S. Roy, S. Roy, V. Sabbisetti, W.M. Saltzman, P.J. Santangelo, D.J. Segal, M. Shimoyama, M.C. Skala, A.F. Tarantal, J.C. Tilton, G.A. Truskey, M. Vandsburger, J.K. Watts, K.D. Wells, S.A. Wolfe, Q. Xu, W. Xue, G. Yi & J. Zhou. Nature 592, 195-204 (2021). DOI
Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model. T. Yang, H. Han, Y. Chen, L. Yang, R. Parker, Y. Li, D.L. Kaplan & Q. Xu. Bioact Mater 6, 3671-3677 (2021). DOI
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of<i>Angptl3</i>. M. Qiu, Z. Glass, J. Chen, M. Haas, X. Jin, X. Zhao, X. Rui, Z. Ye, Y. Li, F. Zhang & Q. Xu. Proceedings of the National Academy of Sciences 118, e2020401118 (2021). DOI
In Vivo Activation of Pro-Protein Therapeutics via Chemically Engineered Enzyme Cascade Reaction. X. Yang, J. Chang, Y. Jiang, Q. Xu, M. Wang & L. Mao. CCS Chemistry 3, 780-790 (2021). DOI
Enhanced protein degradation by intracellular delivery of pre-fused PROTACs using lipid-like nanoparticles. J. Chen, M. Qiu, F. Ma, L. Yang, Z. Glass & Q. Xu. Journal of Controlled Release : Official Journal of the Controlled Release Society 330, 1244-1249 (2021). DOI
Intracellular Antibody Delivery Mediated by Lipids, Polymers, and Inorganic Nanomaterials for Therapeutic Applications. Y. Li, P. Li, R. Li & Q. Xu. Advanced Therapeutics 3, 2000178 (2020). DOI
mRNA Delivery Using Bioreducible Lipidoid Nanoparticles Facilitates Neural Differentiation of Human Mesenchymal Stem Cells. X. Zhao, Z. Glass, J. Chen, L. Yang, D.L. Kaplan & Q. Xu. Advanced Healthcare Materials 10, 2000938 (2021). DOI
Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. F. Ma, L. Yang, Z. Sun, J. Chen, X. Rui, Z. Glass & Q. Xu. Science Advances 6, eabb4429 (2020). DOI
Imidazole‐Based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes. X. Zhao, J. Chen, M. Qiu, Y. Li, Z. Glass & Q. Xu. Angewandte Chemie International Edition 59, 20083-20089 (2020). DOI
Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery. Y. Li, R. Li, A. Chakraborty, R. Ogurlu, X. Zhao, J. Chen & Q. Xu. Bioconjug Chem 31, 1835-1843 (2020). DOI
Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid Nanoparticles. Y. Li, R. Jarvis, K. Zhu, Z. Glass, R. Ogurlu, P. Gao, P. Li, J. Chen, Y. Yu, Y. Yang & Q. Xu. Angewandte Chemie International Edition 59, 14957-14964 (2020). DOI
The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization. T. Yang, Y. Li, Y. Hong, L. Chi, C. Liu, Y. Lan, Q. Wang, Y. Yu, Q. Xu & W. Teng. Front Bioeng Biotechnol 8, 341 (2020). DOI
Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo. L. Yang, F. Ma, F. Liu, J. Chen, X. Zhao & Q. Xu. Mol Ther Nucleic Acids 19, 1357-1367 (2020). DOI
In Vitro and In Vivo Study of Amphotericin B Formulation with Quaternized Bioreducible Lipidoids. F. Liu, L. Yang, Y. Li, A. Junier, F. Ma, J. Chen, H. Han, Z. Glass, X. Zhao, C.A. Kumamoto, H. Sang & Q. Xu. ACS Biomaterials Science & Engineering 6, 1064-1073 (2020). DOI
Ex vivo cell-based CRISPR/Cas9 genome editing for therapeutic applications. Y. Li, Z. Glass, M. Huang, Z.-Y. Chen & Q. Xu. Biomaterials 234, 119711 (2020). DOI
Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing. J. Chang, X. Chen, Z. Glass, F. Gao, L. Mao, M. Wang & Q. Xu. Acc Chem Res 52, 665-675 (2019). DOI
Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties. Parker, Wu, McKay, Xu & Kaplan. Journal of Functional Biomaterials 10, 49 (2019). DOI
Nonviral Nanoparticles for CRISPR-Based Genome Editing: Is It Just a Simple Adaption of What Have Been Developed for Nucleic Acid Delivery? M. Qiu, Z. Glass & Q. Xu. Biomacromolecules 20, 3333-3339 (2019). DOI
Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles. J. Liu, J. Chang, Y. Jiang, X. Meng, T. Sun, L. Mao, Q. Xu & M. Wang. Advanced Materials 31, 1902575 (2019). DOI
Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery. Y. Li, A. Chakraborty, J. Chen & Q. Xu. ACS Biomaterials Science & Engineering 5, 2391-2398 (2019). DOI
Developing chemically modified redox-responsive proteins as smart therapeutics. Q. Tang, J. Wang, Y. Jiang, M. Zhang, J. Chang, Q. Xu, L. Mao & M. Wang. Chemical Communications 55, 5163-5166 (2019). DOI
A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases. X. Ma, P. Zhou, A. Kugelmass, D. Toskic, M. Warner, L. Lee, T. Fogaren, A. Godara, M. Wang, Y. Li, L. Yang, Q. Xu & R.L. Comenzo. Gene Therapy 26, 187-197 (2019). DOI
Evaluation of an elastic decellularized tendon‐derived scaffold for the vascular tissue engineering application. S. Ghazanfari, K.A. Alberti, Q. Xu & A. Khademhosseini. Journal of Biomedical Materials Research Part A 107, 1225-1234 (2019). DOI
Polymer Amphiphiles for Photoregulated Anticancer Drug Delivery. V. Brega, F. Scaletti, X. Zhang, L.-S. Wang, P. Li, Q. Xu, V.M. Rotello & S.W. Thomas. ACS Applied Materials & Interfaces 11, 2814-2820 (2019). DOI
Intracellular Delivery of His-Tagged Genome-Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles. Y. Li, A.C. Li & Q. Xu. Advanced Healthcare Materials 8, e1800996 (2019). DOI
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. B. Bahmani, M. Uehara, L. Jiang, F. Ordikhani, N. Banouni, T. Ichimura, Z. Solhjou, G.J. Furtmüller, G. Brandacher, D. Alvarez, U.H. von Andrian, K. Uchimura, Q. Xu, I. Vohra, O.A. Yilmam, Y. Haik, J. Azzi, V. Kasinath, J.S. Bromberg, M.M. McGrath & R. Abdi. J Clin Invest 128, 4770-4786 (2018). DOI
Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles. Y. Li, J. Bolinger, Y. Yu, Z. Glass, N. Shi, L. Yang, M. Wang & Q. Xu. Biomaterials Science 7, 596-606 (2019). DOI
Rescued from the fate of neurological disorder. Y. Li, Z. Glass & Q. Xu. Nature Biomedical Engineering 2, 469-470 (2018). DOI
A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. L. Sui, M. Wang, Q. Han, L. Yu, L. Zhang, L. Zheng, J. Lian, J. Zhang, P. Valverde, Q. Xu, Q. Tu & J. Chen. Biomaterials 177, 88-97 (2018). DOI
Parabacteroides distasonis attenuates colonic inflammation and prevents tumor formation in azoxymethane-treated high-fat diet-fed mice. G.Y. Koh, A.V. Kane, K. Lee, Q. Xu, X. Wu, J.B. Mason & J.W. Crott. The FASEB Journal 31, 435.432-435.432 (2018). DOI
Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. G.Y. Koh, A. Kane, K. Lee, Q. Xu, X. Wu, J. Roper, J.B. Mason & J.W. Crott. Int J Cancer 143, 1797-1805 (2018). DOI
Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Y. Li, T. Yang, Y. Yu, N. Shi, L. Yang, Z. Glass, J. Bolinger, I.J. Finkel, W. Li & Q. Xu. Biomaterials 178, 652-662 (2018). DOI
Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. Z.-M. Chang, Z. Wang, D. Shao, J. Yue, H. Xing, L. Li, M. Ge, M. Li, H. Yan, H. Hu, Q. Xu & W.-F. Dong. ACS Appl Mater Interfaces 10, 10656-10663 (2018). DOI
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. X. Gao, Y. Tao, V. Lamas, M. Huang, W.-H. Yeh, B. Pan, Y.-J. Hu, J.H. Hu, D.B. Thompson, Y. Shu, Y. Li, H. Wang, S. Yang, Q. Xu, D.B. Polley, M.C. Liberman, W.-J. Kong, J.R. Holt, Z.-Y. Chen & D.R. Liu. Nature 553, 217-221 (2018). DOI
Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma. Z. Wang, D. Shao, Z. Chang, M. Lu, Y. Wang, J. Yue, D. Yang, M. Li, Q. Xu & W.-F. Dong. ACS Nano 11, 12732-12741 (2017). DOI
Nanoparticles for CRISPR-Cas9 delivery. Z. Glass, Y. Li & Q. Xu. Nature Biomedical Engineering 1, 854-855 (2017). DOI
Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags. R. Tang, M. Wang, M. Ray, Y. Jiang, Z. Jiang, Q. Xu & V.M. Rotello. Journal of the American Chemical Society 139, 8547-8551 (2017). DOI
Pulling Cancer Cells Apart with a Net of Nanofibers. Q. Xu & C.I. Neufeld. Chem 2, 167-168 (2017). DOI
Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles. X. Wang, Y. Li, Q. Li, C.I. Neufeld, D. Pouli, S. Sun, L. Yang, P. Deng, M. Wang, I. Georgakoudi, S. Tang & Q. Xu. Journal of Controlled Release : Official Journal of the Controlled Release Society 263, 39-45 (2017). DOI
Hyper-Crosslinkers Lead to Temperature- and pH-Responsive Polymeric Nanogels with Unusual Volume Change. N. Zhou, X. Cao, X. Du, H. Wang, M. Wang, S. Liu, K. Nguyen, K. Schmidt-Rohr, Q. Xu, G. Liang & B. Xu. Angew Chem Int Ed Engl 56, 2623-2627 (2017). DOI
Non-viral delivery of genome-editing nucleases for gene therapy. M. Wang, Z.A. Glass & Q. Xu. Gene Therapy 24, 144-150 (2017). DOI
Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. S.A. Altınoğlu, M. Wang, K.Q. Li, Y. Li & Q. Xu. Biomaterials Science 4, 1773-1780 (2016). DOI
Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes. X. Hu, M.J. Feeney, E. McIntosh, J. Mullahoo, F. Jia, Q. Xu & S.W. Thomas. ACS Appl Mater Interfaces 8, 23517-23522 (2016). DOI
Nanostructured Tendon-Derived Scaffolds for Enhanced Bone Regeneration by Human Adipose-Derived Stem Cells. E. Ko, K. Alberti, J.S. Lee, K. Yang, Y. Jin, J. Shin, H.S. Yang, Q. Xu & S.-W. Cho. ACS Appl Mater Interfaces 8, 22819-22829 (2016). DOI
A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics. P. Mostafalu, M. Akbari, K.A. Alberti, Q. Xu, A. Khademhosseini & S.R. Sonkusale. Microsyst Nanoeng 2, 16039 (2016). DOI
Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring. Y. Jiang, M. Wang, J. Hardie, G.Y. Tonga, M. Ray, Q. Xu & V.M. Rotello. Small 12, 3775-3779 (2016). DOI
In Vivo Peripheral Nerve Repair Using Tendon-Derived Nerve Guidance Conduits. K.A. Alberti, C.I. Neufeld, J. Wang & Q. Xu. ACS Biomaterials Science & Engineering 2, 937-945 (2016). DOI
The matrix reloaded: the evolution of regenerative hydrogels. E. Jabbari, J. Leijten, Q. Xu & A. Khademhosseini. Materials Today 19, 190-196 (2016). DOI
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. M. Wang, J.A. Zuris, F. Meng, H. Rees, S. Sun, P. Deng, Y. Han, X. Gao, D. Pouli, Q. Wu, I. Georgakoudi, D.R. Liu & Q. Xu. Proceedings of the National Academy of Sciences of the United States of America 113, 2868-2873 (2016). DOI
A rodent model for non-surgical sterilization using an antibody-guided lipid nanoparticle cytotoxin delivery system Q.X. K. Meadows, S. Ayresa Clinical Theriogenology 8, 3 (2016). DOI
Biocompatibility and degradation of tendon-derived scaffolds. K.A. Alberti & Q. Xu. Regen Biomater 3(2016). DOI
Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery. M. Wang, S. Altinoglu, Y.S. Takeda & Q. Xu. PloS One 10, e0141860 (2015). DOI
Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands. L.J. Domigan, M. Andersson, K.A. Alberti, M. Chesler, Q. Xu, J. Johansson, A. Rising & D.L. Kaplan. Insect Biochem Mol Biol 65, 100-106 (2015). DOI
Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells. Y.S. Takeda & Q. Xu. PloS One 10, e0135111 (2015). DOI
Synthetic and nature-derived lipid nanoparticles for neural regeneration. Y.S. Takeda & Q. Xu. Neural Regen Res 10, 689-690 (2015). DOI
Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications. S. Altinoglu, M. Wang & Q. Xu. Nanomedicine (Lond) 10, 643-657 (2015). DOI
Laminar Tendon Composites with Enhanced Mechanical Properties. K.A. Alberti, J.-Y. Sun, W.R. Illeperuma, Z. Suo & Q. Xu. J Mater Sci 50, 2616-2625 (2015). DOI
Fabrication of 2D and 3D constructs from reconstituted decellularized tissue extracellular matrices. Y.S. Takeda & Q. Xu. J Biomed Nanotechnol 10, 3631-3637 (2014). DOI
Emerging therapies targeting intra-organ inflammation in transplantation. Z. Solhjou, H. Athar, Q. Xu & R. Abdi. Am J Transplant 15, 305-311 (2014). DOI
Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy. M. Wang, S. Sun, C.I. Neufeld, B. Perez-Ramirez & Q. Xu. Angew Chem Int Ed Engl 53, 13444-13448 (2014). DOI
Pericellular hydrogel/nanonets inhibit cancer cells. Y. Kuang, J. Shi, J. Li, D. Yuan, K.A. Alberti, Q. Xu & B. Xu. Angew Chem Int Ed Engl 53, 8104-8107 (2014). DOI
Genetically programmable thermoresponsive plasmonic gold/silk-elastin protein core/shell nanoparticles. Y. Lin, X. Xia, M. Wang, Q. Wang, B. An, H. Tao, Q. Xu, F. Omenetto & D.L. Kaplan. Langmuir : the ACS Journal of Surfaces and Colloids 30, 4406-4414 (2014). DOI
High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials. Q. Wang, X. Xia, W. Huang, Y. Lin, Q. Xu & D.L. Kaplan. Adv Funct Mater 24, 4303-4310 (2014). DOI
Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery. X.-X. Xia, M. Wang, Y. Lin, Q. Xu & D.L. Kaplan. Biomacromolecules 15, 908-914 (2014). DOI
Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles. M. Wang, K. Alberti, A. Varone, D. Pouli, I. Georgakoudi & Q. Xu. Advanced Healthcare Materials 3, 1398-1403 (2014). DOI
Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy. M. Wang, K. Alberti, S. Sun, C.L. Arellano & Q. Xu. Angew Chem Int Ed Engl 53, 2893-2898 (2014). DOI
The behavior of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration. K.A. Alberti, A.M. Hopkins, M.D. Tang-Schomer, D.L. Kaplan & Q. Xu. Biomaterials 35, 3551-3557 (2014). DOI
DOPE facilitates quaternized lipidoids (QLDs) for in vitro DNA delivery. S. Sun, M. Wang, K.A. Alberti, A. Choy & Q. Xu. Nanomedicine 9, 849-854 (2013). DOI
All electronic approach for high-throughput cell trapping and lysis with electrical impedance monitoring. S.K. Ameri, P.K. Singh, M.R. Dokmeci, A. Khademhosseini, Q. Xu & S.R. Sonkusale. Biosens Bioelectron 54, 462-467 (2013). DOI
Slicing, stacking and rolling: fabrication of nanostructured collagen constructs from tendon sections. K.A. Alberti & Q. Xu. Advanced Healthcare Materials 2, 817-821 (2013). DOI
A combinatorial library of unsaturated lipidoids for efficient intracellular gene delivery. M. Wang, S. Sun, K.A. Alberti & Q. Xu. ACS Synth Biol 1, 403-407 (2012). DOI
Patterning nanoparticles in a three-dimensional matrix using an electric-field-assisted gel transferring technique. X. Dai, S.A. Knupp & Q. Xu. Langmuir : the ACS Journal of Surfaces and Colloids 28, 2960-2964 (2012). DOI
Combinatorial library of lipidoids for in vitro DNA delivery. S. Sun, M. Wang, S.A. Knupp, Y. Soto-Feliciano, X. Hu, D.L. Kaplan, R. Langer, D.G. Anderson & Q. Xu. Bioconjug Chem 23, 135-140 (2012). DOI
Staining and etching: a simple method to fabricate inorganic nanostructures from tissue slices. X. Dai, R. Schalek & Q. Xu. Adv Mater 24, 370-374 (2011). DOI
Microfabrication technologies for oral drug delivery. S. Sant, S.L. Tao, O.Z. Fisher, Q. Xu, N.A. Peppas & A. Khademhosseini. Advanced Drug Delivery Reviews 64, 496-507 (2012). DOI
Nanostructured substrate fabricated by sectioning tendon using a microtome for tissue engineering. X. Dai & Q. Xu. Nanotechnology 22, 494008 (2011). DOI
Tunable self-assembly of genetically engineered silk–elastin-like protein polymers. X.-X. Xia, Q. Xu, X. Hu, G. Qin & D.L. Kaplan. Biomacromolecules 12, 3844-3850 (2011). DOI
Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. H. Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M. Ma, S.R. Bogatyrev, Q. Xu, K.A. Whitehead, R. Langer & D.G. Anderson. ACS Nano 4, 625-631 (2010). DOI
An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation. B. Huo, X.L. Lu, K.D. Costa, Q. Xu & X.E. Guo. Cell Calcium 47, 234-241 (2010). DOI
Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules. T.T. Dang, Q. Xu, K.M. Bratlie, E.S. O’Sullivan, X.Y. Chen, R. Langer & D.G. Anderson. Biomaterials 30, 6896-6902 (2009). DOI
Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells. S.W. Cho, M. Goldberg, S.M. Son, Q. Xu, F. Yang, Y. Mei, S. Bogatyrev, R. Langer & D.G. Anderson. Adv Funct Mater 19, 3112-3118 (2009). DOI
Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Q. Xu, M. Hashimoto, T.T. Dang, T. Hoare, D.S. Kohane, G.M. Whitesides, R. Langer & D.G. Anderson. Small 5, 1575-1581 (2009). DOI
Nanoskiving: a new method to produce arrays of nanostructures. Q. Xu, R.M. Rioux, M.D. Dickey & G.M. Whitesides. Acc Chem Res 41, 1566-1577 (2008). DOI
Nanoskiving: a novel method for nanofabrication and its applications in nanophotonics. X. Qiaobing & M.W. George. in Proc.SPIE, Vol. 7205 72050P (2009). DOI
Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. S.W. Cho, L. Hartle, S.M. Son, F. Yang, M. Goldberg, Q. Xu, R. Langer & D.G. Anderson. Biochem Biophys Res Commun 376, 158-163 (2008). DOI
Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Y. Mei, C. Cannizzaro, H. Park, Q. Xu, S.R. Bogatyrev, K. Yi, N. Goldman, R. Langer & D.G. Anderson. Small 4, 1600-1604 (2008). DOI
Fluid Flow Induced Calcium Response in Bone Cell Network. B. Huo, X.L. Lu, C.T. Hung, K.D. Costa, Q. Xu, G.M. Whitesides & X.E. Guo. Cell Mol Bioeng 1, 58-66 (2008). DOI
Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. N. Xia, C.K. Thodeti, T.P. Hunt, Q. Xu, M. Ho, G.M. Whitesides, R. Westervelt & D.E. Ingber. Faseb j 22, 1649-1659 (2008). DOI
Fabrication of complex metallic nanostructures by nanoskiving. Q. Xu, R.M. Rioux & G.M. Whitesides. ACS Nano 1, 215-227 (2007). DOI
Fabrication of large-area patterned nanostructures for optical applications by nanoskiving. Q. Xu, J. Bao, R.M. Rioux, R. Perez-Castillejos, F. Capasso & G.M. Whitesides. Nano Lett 7, 2800-2805 (2007). DOI
Intracellular calcium waves in bone cell networks under single cell nanoindentation. X.E. Guo, E. Takai, X. Jiang, Q. Xu, G.M. Whitesides, J.T. Yardley, C.T. Hung, E.M. Chow, T. Hantschel & K.D. Costa. Mol Cell Biomech 3, 95-107 (2006). DOI
Core-shell and segmented polymer-metal composite nanostructures. M. Lahav, E.A. Weiss, Q. Xu & G.M. Whitesides. Nano Lett 6, 2166-2171 (2006). DOI
Fabrication of high-aspect-ratio metallic nanostructures using nanoskiving. Q. Xu, R. Perez-Castillejos, Z. Li & G.M. Whitesides. Nano Lett 6, 2163-2165 (2006). DOI
Surface plasmon resonances of free-standing gold nanowires fabricated by nanoskiving. Q. Xu, J. Bao, F. Capasso & G.M. Whitesides. Angew Chem Int Ed Engl 45, 3631-3635 (2006). DOI
Fabrication of thin, metallic films along the sidewalls of a topographically patterned stamp and their application in charge printing. T. Cao, Q. Xu, A. Winkleman & G.M. Whitesides. Small 1, 1191-1195 (2005). DOI
A general method for patterning gradients of biomolecules on surfaces using microfluidic networks. X. Jiang, Q. Xu, S.K. Dertinger, A.D. Stroock, T.M. Fu & G.M. Whitesides. Anal Chem 77, 2338-2347 (2005). DOI
New approaches to nanofabrication: molding, printing, and other techniques. B.D. Gates, Q. Xu, M. Stewart, D. Ryan, C.G. Willson & G.M. Whitesides. Chem Rev 105, 1171-1196 (2005). DOI
Approaching zero: using fractured crystals in metrology for replica molding. Q. Xu, B.T. Mayers, M. Lahav, D.V. Vezenov & G.M. Whitesides. J Am Chem Soc 127, 854-855 (2004). DOI
Fabrication of Free-Standing Metallic Pyramidal Shells. Q. Xu, I. Tonks, M.J. Fuerstman, J.C. Love & G.M. Whitesides. Nano Letters 4, 2509-2511 (2004). DOI
Shear patterning of microdominos: a new class of procedures for making micro- and nanostructures. B.D. Gates, Q. Xu, V.R. Thalladi, T. Cao, T. Knickerbocker & G.M. Whitesides. Angew Chem Int Ed Engl 43, 2780-2783 (2004). DOI
UNCONVENTIONAL NANOFABRICATION. B.D. Gates, Q. Xu, J.C. Love, D.B. Wolfe & G.M. Whitesides. Annual Review of Materials Research 34, 339-372 (2004). DOI
Fabrication of metal structures with nanometer-scale lateral dimensions by sectioning using a microtome. Q. Xu, B.D. Gates & G.M. Whitesides. J Am Chem Soc 126, 1332-1333 (2004). DOI
Supramolecular research by single molecule force Spectroscopy. W. Zhang, Q. Xu, C. Wang & X. Zhang. Macromolecular Symposia 195, 109-114 (2003). DOI
Oxygen Bridge Inhibits Conformational Transition of 1,4-Linked α-d-Galactose Detected by Single-Molecule Atomic Force Microscopy. Q. Xu, W. Zhang & X. Zhang. Macromolecules 35, 871-876 (2002). DOI
Single-Molecule Force Spectroscopy on Carrageenan by Means of AFM. Q. Xu, S. Zou, W. Zhang & X. Zhang. Macromolecular Rapid Communications 22, 1163-1167 (2001). DOI
Single-Molecule Force Spectroscopy on Bombyx mori Silk Fibroin by Atomic Force Microscopy. W. Zhang, Q. Xu, S. Zou, H. Li, W. Xu, X. Zhang, Z. Shao, M. Kudera & H.E. Gaub. Langmuir 16, 4305-4308 (2000). DOI
