Peer-reviewed Paper

  1. Investigating the Cytosolic Delivery of Proteins by Lipid Nanoparticles Using the Chloroalkane Penetration Assay. J. Wang, S. Zhang, Y. Li, Q. Xu & J.A. Kritzer. Biochemistry (2024). DOI
  2. Harnessing non-Watson-Crick’s base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells. S. Gao, H. Guan, H. Bloomer, D. Wich, D. Song, J. Khirallah, Z. Ye, Y. Zhao, M. Chen, C. Xu, L. Liu & Q. Xu. Proc Natl Acad Sci U S A 121, e2308415120 (2024). DOI
  3. Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants. Z. Ye, S.R. Bonam, L.G.A. McKay, J.A. Plante, J. Walker, Y. Zhao, C. Huang, J. Chen, C. Xu, Y. Li, L. Liu, J. Harmon, S. Gao, D. Song, Z. Zhang, K.S. Plante, A. Griffiths, J. Chen, H. Hu & Q. Xu. Proc Natl Acad Sci U S A 120, e2311752120 (2023). DOI
  4. Nanomechanical action opens endo-lysosomal compartments. Y. Zhao, Z. Ye, D. Song, D. Wich, S. Gao, J. Khirallah & Q. Xu. Nat Commun 14, 6645 (2023). DOI
  5. A high-throughput approach of screening nanoparticles for targeted delivery of mRNA. J. Khirallah & Q. Xu. Cell Rep Methods 3, 100572 (2023). DOI
  6. The mRNA Vaccine Revolution: COVID-19 Has Launched the Future of Vaccinology. Z. Ye, J. Harmon, W. Ni, Y. Li, D. Wich & Q. Xu. ACS Nano 17, 15231-15253 (2023). DOI
  7. Gemini Amphiphiles: Robust Cytosolic Delivery of Therapeutic Biomacromolecules through Non-Endocytic Translocation Pathways. Y. Zhao, D. Wich & Q. Xu. ACS Cent Sci 9, 1266-1268 (2023). DOI
  8. A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Z.A. Ely, N. Mathey-Andrews, S. Naranjo, S.I. Gould, K.L. Mercer, G.A. Newby, C.M. Cabana, W.M. Rideout, 3rd, G.C. Jaramillo, J.M. Khirallah, K. Holland, P.B. Randolph, W.A. Freed-Pastor, J.R. Davis, Z. Kulstad, P.M.K. Westcott, L. Lin, A.V. Anzalone, B.L. Horton, N.B. Pattada, S.L. Shanahan, Z. Ye, S. Spranger, Q. Xu, F.J. Sanchez-Rivera, D.R. Liu & T. Jacks. Nat Biotechnol 42, 424-436 (2023). DOI
  9. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta. B. Carter, P. Huang, G. Liu, Y. Liang, P.J.C. Lin, B.H. Peng, L.G.A. McKay, A. Dimitrakakis, J. Hsu, V. Tat, P. Saenkham-Huntsinger, J. Chen, C. Kaseke, G.D. Gaiha, Q. Xu, A. Griffiths, Y.K. Tam, C.K. Tseng & D.K. Gifford. Front Immunol 14, 1135815 (2023). DOI
  10. Clinical progress in genome-editing technology and in vivo delivery techniques. J. Khirallah, M. Eimbinder, Y. Li & Q. Xu. Trends Genet 39, 208-216 (2023). DOI
  11. Lipidoid Artificial Compartments for Bidirectional Regulation of Enzyme Activity through Nanomechanical Action. Y. Zhao, S. Gao, D. Song, Z. Ye, R. Xu, Y. Luo & Q. Xu. J Am Chem Soc 145, 551-559 (2022). DOI
  12. Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8(+) T cell response. J. Chen, Z. Ye, C. Huang, M. Qiu, D. Song, Y. Li & Q. Xu. Proc Natl Acad Sci U S A 119, e2207841119 (2022). DOI
  13. Engineering a Nano/Biointerface for Cell and Organ-Selective Drug Delivery. D. Song & Q. Xu. Langmuir 38, 9092-9098 (2022). DOI
  14. The effects of protein corona on in vivo fate of nanocarriers. Q. Xiao, M. Zoulikha, M. Qiu, C. Teng, C. Lin, X. Li, M.A. Sallam, Q. Xu & W. He. Adv Drug Deliv Rev 186, 114356 (2022). DOI
  15. Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs. Y. Li, Z. Ye, H. Yang & Q. Xu. Acta Pharm Sin B 12, 2624-2639 (2022). DOI
  16. Current Developments and Challenges of mRNA Vaccines. J. Chen, J. Chen & Q. Xu. Annu Rev Biomed Eng 24, 85-109 (2022). DOI
  17. Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. M. Qiu, Y. Tang, J. Chen, R. Muriph, Z. Ye, C. Huang, J. Evans, E.P. Henske & Q. Xu. Proc Natl Acad Sci U S A 119(2022). DOI
  18. Challenges in delivering therapeutic peptides and proteins: A silk-based solution. J. Wu, J.K. Sahoo, Y. Li, Q. Xu & D.L. Kaplan. J Control Release 345, 176-189 (2022). DOI
  19. In Vitro Engineering Chimeric Antigen Receptor Macrophages and T Cells by Lipid Nanoparticle-Mediated mRNA Delivery. Z. Ye, J. Chen, X. Zhao, Y. Li, J. Harmon, C. Huang, J. Chen & Q. Xu. ACS Biomater Sci Eng 8, 722-733 (2022). DOI
  20. CRISPR/Cas9 ribonucleoprotein-mediated genome and epigenome editing in mammalian cells. H. Bloomer, J. Khirallah, Y. Li & Q. Xu. Adv Drug Deliv Rev 181, 114087 (2022). DOI
  21. Intracellular Delivery of Antibodies for Selective Cell Signaling Interference. R.L. Hershman, Y. Li, F. Ma, Q. Xu & J.A. Van Deventer. ChemMedChem 17(2022). DOI
  22. Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing. M. Qiu, Y. Li, H. Bloomer & Q. Xu. Acc Chem Res 54, 4001-4011 (2021). DOI
  23. Osteogenic effects of microRNA-335-5p/lipidoid nanoparticles coated on titanium surface. Q. Wang, X. Wang, P. Valverde, D. Murray, M.M. Dard, T. Van Dyke, Q. Xu, X. Xu, N. Karimbux, Q. Tu & J. Chen. Archives of Oral Biology 129, 105207 (2021). DOI
  24. Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy. T.-C. Ho, H.S. Kim, Y. Chen, Y. Li, M.W. Lamere, C. Chen, H. Wang, J. Gong, C.D. Palumbo, J.M. Ashton, H.-W. Kim, Q. Xu, M.W. Becker & K.W. Leong. Science Advances 7, eabg3217 (2021). DOI
  25. In situ cancer vaccination using lipidoid nanoparticles. J. Chen, M. Qiu, Z. Ye, T. Nyalile, Y. Li, Z. Glass, X. Zhao, L. Yang, J. Chen & Q. Xu. Science Advances 7(2021). DOI
  26. Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice. C. Brandon, C. Jinjin, K. Clarety, D. Alexander, D.G. Gaurav, X. Qiaobing & K.G. David. bioRxiv, 2021.2005.2002.442052 (2021). DOI
  27. The NIH Somatic Cell Genome Editing program. K. Saha, E.J. Sontheimer, P.J. Brooks, M.R. Dwinell, C.A. Gersbach, D.R. Liu, S.A. Murray, S.Q. Tsai, R.C. Wilson, D.G. Anderson, A. Asokan, J.F. Banfield, K.S. Bankiewicz, G. Bao, J.W.M. Bulte, N. Bursac, J.M. Campbell, D.F. Carlson, E.L. Chaikof, Z.-Y. Chen, R.H. Cheng, K.J. Clark, D.T. Curiel, J.E. Dahlman, B.E. Deverman, M.E. Dickinson, J.A. Doudna, S.C. Ekker, M.E. Emborg, G. Feng, B.S. Freedman, D.M. Gamm, G. Gao, I.C. Ghiran, P.M. Glazer, S. Gong, J.D. Heaney, J.D. Hennebold, J.T. Hinson, A. Khvorova, S. Kiani, W.R. Lagor, K.S. Lam, K.W. Leong, J.E. Levine, J.A. Lewis, C.M. Lutz, D.H. Ly, S. Maragh, P.B. McCray, T.C. McDevitt, O. Mirochnitchenko, R. Morizane, N. Murthy, R.S. Prather, J.A. Ronald, S. Roy, S. Roy, V. Sabbisetti, W.M. Saltzman, P.J. Santangelo, D.J. Segal, M. Shimoyama, M.C. Skala, A.F. Tarantal, J.C. Tilton, G.A. Truskey, M. Vandsburger, J.K. Watts, K.D. Wells, S.A. Wolfe, Q. Xu, W. Xue, G. Yi & J. Zhou. Nature 592, 195-204 (2021). DOI
  28. Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model. T. Yang, H. Han, Y. Chen, L. Yang, R. Parker, Y. Li, D.L. Kaplan & Q. Xu. Bioact Mater 6, 3671-3677 (2021). DOI
  29. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of<i>Angptl3</i>. M. Qiu, Z. Glass, J. Chen, M. Haas, X. Jin, X. Zhao, X. Rui, Z. Ye, Y. Li, F. Zhang & Q. Xu. Proceedings of the National Academy of Sciences 118, e2020401118 (2021). DOI
  30. In Vivo Activation of Pro-Protein Therapeutics via Chemically Engineered Enzyme Cascade Reaction. X. Yang, J. Chang, Y. Jiang, Q. Xu, M. Wang & L. Mao. CCS Chemistry 3, 780-790 (2021). DOI
  31. Enhanced protein degradation by intracellular delivery of pre-fused PROTACs using lipid-like nanoparticles. J. Chen, M. Qiu, F. Ma, L. Yang, Z. Glass & Q. Xu. Journal of Controlled Release : Official Journal of the Controlled Release Society 330, 1244-1249 (2021). DOI
  32. Intracellular Antibody Delivery Mediated by Lipids, Polymers, and Inorganic Nanomaterials for Therapeutic Applications. Y. Li, P. Li, R. Li & Q. Xu. Advanced Therapeutics 3, 2000178 (2020). DOI
  33. mRNA Delivery Using Bioreducible Lipidoid Nanoparticles Facilitates Neural Differentiation of Human Mesenchymal Stem Cells. X. Zhao, Z. Glass, J. Chen, L. Yang, D.L. Kaplan & Q. Xu. Advanced Healthcare Materials 10, 2000938 (2021). DOI
  34. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. F. Ma, L. Yang, Z. Sun, J. Chen, X. Rui, Z. Glass & Q. Xu. Science Advances 6, eabb4429 (2020). DOI
  35. Imidazole‐Based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes. X. Zhao, J. Chen, M. Qiu, Y. Li, Z. Glass & Q. Xu. Angewandte Chemie International Edition 59, 20083-20089 (2020). DOI
  36. Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery. Y. Li, R. Li, A. Chakraborty, R. Ogurlu, X. Zhao, J. Chen & Q. Xu. Bioconjug Chem 31, 1835-1843 (2020). DOI
  37. Protein and mRNA Delivery Enabled by Cholesteryl‐Based Biodegradable Lipidoid Nanoparticles. Y. Li, R. Jarvis, K. Zhu, Z. Glass, R. Ogurlu, P. Gao, P. Li, J. Chen, Y. Yu, Y. Yang & Q. Xu. Angewandte Chemie International Edition 59, 14957-14964 (2020). DOI
  38. The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization. T. Yang, Y. Li, Y. Hong, L. Chi, C. Liu, Y. Lan, Q. Wang, Y. Yu, Q. Xu & W. Teng. Front Bioeng Biotechnol 8, 341 (2020). DOI
  39. Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo. L. Yang, F. Ma, F. Liu, J. Chen, X. Zhao & Q. Xu. Mol Ther Nucleic Acids 19, 1357-1367 (2020). DOI
  40. In Vitro and In Vivo Study of Amphotericin B Formulation with Quaternized Bioreducible Lipidoids. F. Liu, L. Yang, Y. Li, A. Junier, F. Ma, J. Chen, H. Han, Z. Glass, X. Zhao, C.A. Kumamoto, H. Sang & Q. Xu. ACS Biomaterials Science & Engineering 6, 1064-1073 (2020). DOI
  41. Ex vivo cell-based CRISPR/Cas9 genome editing for therapeutic applications. Y. Li, Z. Glass, M. Huang, Z.-Y. Chen & Q. Xu. Biomaterials 234, 119711 (2020). DOI
  42. Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing. J. Chang, X. Chen, Z. Glass, F. Gao, L. Mao, M. Wang & Q. Xu. Acc Chem Res 52, 665-675 (2019). DOI
  43. Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties. Parker, Wu, McKay, Xu & Kaplan. Journal of Functional Biomaterials 10, 49 (2019). DOI
  44. Nonviral Nanoparticles for CRISPR-Based Genome Editing: Is It Just a Simple Adaption of What Have Been Developed for Nucleic Acid Delivery? M. Qiu, Z. Glass & Q. Xu. Biomacromolecules 20, 3333-3339 (2019). DOI
  45. Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles. J. Liu, J. Chang, Y. Jiang, X. Meng, T. Sun, L. Mao, Q. Xu & M. Wang. Advanced Materials 31, 1902575 (2019). DOI
  46. Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery. Y. Li, A. Chakraborty, J. Chen & Q. Xu. ACS Biomaterials Science & Engineering 5, 2391-2398 (2019). DOI
  47. Developing chemically modified redox-responsive proteins as smart therapeutics. Q. Tang, J. Wang, Y. Jiang, M. Zhang, J. Chang, Q. Xu, L. Mao & M. Wang. Chemical Communications 55, 5163-5166 (2019). DOI
  48. A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases. X. Ma, P. Zhou, A. Kugelmass, D. Toskic, M. Warner, L. Lee, T. Fogaren, A. Godara, M. Wang, Y. Li, L. Yang, Q. Xu & R.L. Comenzo. Gene Therapy 26, 187-197 (2019). DOI
  49. Evaluation of an elastic decellularized tendon‐derived scaffold for the vascular tissue engineering application. S. Ghazanfari, K.A. Alberti, Q. Xu & A. Khademhosseini. Journal of Biomedical Materials Research Part A 107, 1225-1234 (2019). DOI
  50. Polymer Amphiphiles for Photoregulated Anticancer Drug Delivery. V. Brega, F. Scaletti, X. Zhang, L.-S. Wang, P. Li, Q. Xu, V.M. Rotello & S.W. Thomas. ACS Applied Materials &amp; Interfaces 11, 2814-2820 (2019). DOI
  51. Intracellular Delivery of His-Tagged Genome-Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles. Y. Li, A.C. Li & Q. Xu. Advanced Healthcare Materials 8, e1800996 (2019). DOI
  52. Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. B. Bahmani, M. Uehara, L. Jiang, F. Ordikhani, N. Banouni, T. Ichimura, Z. Solhjou, G.J. Furtmüller, G. Brandacher, D. Alvarez, U.H. von Andrian, K. Uchimura, Q. Xu, I. Vohra, O.A. Yilmam, Y. Haik, J. Azzi, V. Kasinath, J.S. Bromberg, M.M. McGrath & R. Abdi. J Clin Invest 128, 4770-4786 (2018). DOI
  53. Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles. Y. Li, J. Bolinger, Y. Yu, Z. Glass, N. Shi, L. Yang, M. Wang & Q. Xu. Biomaterials Science 7, 596-606 (2019). DOI
  54. Rescued from the fate of neurological disorder. Y. Li, Z. Glass & Q. Xu. Nature Biomedical Engineering 2, 469-470 (2018). DOI
  55. A novel Lipidoid-MicroRNA formulation promotes calvarial bone regeneration. L. Sui, M. Wang, Q. Han, L. Yu, L. Zhang, L. Zheng, J. Lian, J. Zhang, P. Valverde, Q. Xu, Q. Tu & J. Chen. Biomaterials 177, 88-97 (2018). DOI
  56. Parabacteroides distasonis attenuates colonic inflammation and prevents tumor formation in azoxymethane-treated high-fat diet-fed mice. G.Y. Koh, A.V. Kane, K. Lee, Q. Xu, X. Wu, J.B. Mason & J.W. Crott. The FASEB Journal 31, 435.432-435.432 (2018). DOI
  57. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. G.Y. Koh, A. Kane, K. Lee, Q. Xu, X. Wu, J. Roper, J.B. Mason & J.W. Crott. Int J Cancer 143, 1797-1805 (2018). DOI
  58. Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Y. Li, T. Yang, Y. Yu, N. Shi, L. Yang, Z. Glass, J. Bolinger, I.J. Finkel, W. Li & Q. Xu. Biomaterials 178, 652-662 (2018). DOI
  59. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. Z.-M. Chang, Z. Wang, D. Shao, J. Yue, H. Xing, L. Li, M. Ge, M. Li, H. Yan, H. Hu, Q. Xu & W.-F. Dong. ACS Appl Mater Interfaces 10, 10656-10663 (2018). DOI
  60. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. X. Gao, Y. Tao, V. Lamas, M. Huang, W.-H. Yeh, B. Pan, Y.-J. Hu, J.H. Hu, D.B. Thompson, Y. Shu, Y. Li, H. Wang, S. Yang, Q. Xu, D.B. Polley, M.C. Liberman, W.-J. Kong, J.R. Holt, Z.-Y. Chen & D.R. Liu. Nature 553, 217-221 (2018). DOI
  61. Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma. Z. Wang, D. Shao, Z. Chang, M. Lu, Y. Wang, J. Yue, D. Yang, M. Li, Q. Xu & W.-F. Dong. ACS Nano 11, 12732-12741 (2017). DOI
  62. Nanoparticles for CRISPR-Cas9 delivery. Z. Glass, Y. Li & Q. Xu. Nature Biomedical Engineering 1, 854-855 (2017). DOI
  63. Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags. R. Tang, M. Wang, M. Ray, Y. Jiang, Z. Jiang, Q. Xu & V.M. Rotello. Journal of the American Chemical Society 139, 8547-8551 (2017). DOI
  64. Pulling Cancer Cells Apart with a Net of Nanofibers. Q. Xu & C.I. Neufeld. Chem 2, 167-168 (2017). DOI
  65. Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles. X. Wang, Y. Li, Q. Li, C.I. Neufeld, D. Pouli, S. Sun, L. Yang, P. Deng, M. Wang, I. Georgakoudi, S. Tang & Q. Xu. Journal of Controlled Release : Official Journal of the Controlled Release Society 263, 39-45 (2017). DOI
  66. Hyper-Crosslinkers Lead to Temperature- and pH-Responsive Polymeric Nanogels with Unusual Volume Change. N. Zhou, X. Cao, X. Du, H. Wang, M. Wang, S. Liu, K. Nguyen, K. Schmidt-Rohr, Q. Xu, G. Liang & B. Xu. Angew Chem Int Ed Engl 56, 2623-2627 (2017). DOI
  67. Non-viral delivery of genome-editing nucleases for gene therapy. M. Wang, Z.A. Glass & Q. Xu. Gene Therapy 24, 144-150 (2017). DOI
  68. Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. S.A. Altınoğlu, M. Wang, K.Q. Li, Y. Li & Q. Xu. Biomaterials Science 4, 1773-1780 (2016). DOI
  69. Triggered Release of Encapsulated Cargo from Photoresponsive Polyelectrolyte Nanocomplexes. X. Hu, M.J. Feeney, E. McIntosh, J. Mullahoo, F. Jia, Q. Xu & S.W. Thomas. ACS Appl Mater Interfaces 8, 23517-23522 (2016). DOI
  70. Nanostructured Tendon-Derived Scaffolds for Enhanced Bone Regeneration by Human Adipose-Derived Stem Cells. E. Ko, K. Alberti, J.S. Lee, K. Yang, Y. Jin, J. Shin, H.S. Yang, Q. Xu & S.-W. Cho. ACS Appl Mater Interfaces 8, 22819-22829 (2016). DOI
  71. A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics. P. Mostafalu, M. Akbari, K.A. Alberti, Q. Xu, A. Khademhosseini & S.R. Sonkusale. Microsyst Nanoeng 2, 16039 (2016). DOI
  72. Chemically Engineered Nanoparticle-Protein Interface for Real-Time Cellular Oxidative Stress Monitoring. Y. Jiang, M. Wang, J. Hardie, G.Y. Tonga, M. Ray, Q. Xu & V.M. Rotello. Small 12, 3775-3779 (2016). DOI
  73. In Vivo Peripheral Nerve Repair Using Tendon-Derived Nerve Guidance Conduits. K.A. Alberti, C.I. Neufeld, J. Wang & Q. Xu. ACS Biomaterials Science & Engineering 2, 937-945 (2016). DOI
  74. The matrix reloaded: the evolution of regenerative hydrogels. E. Jabbari, J. Leijten, Q. Xu & A. Khademhosseini. Materials Today 19, 190-196 (2016). DOI
  75. Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles. M. Wang, J.A. Zuris, F. Meng, H. Rees, S. Sun, P. Deng, Y. Han, X. Gao, D. Pouli, Q. Wu, I. Georgakoudi, D.R. Liu & Q. Xu. Proceedings of the National Academy of Sciences of the United States of America 113, 2868-2873 (2016). DOI
  76. A rodent model for non-surgical sterilization using an antibody-guided lipid nanoparticle cytotoxin delivery system Q.X. K. Meadows, S. Ayresa Clinical Theriogenology 8, 3 (2016). DOI
  77. Biocompatibility and degradation of tendon-derived scaffolds. K.A. Alberti & Q. Xu. Regen Biomater 3(2016). DOI
  78. Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery. M. Wang, S. Altinoglu, Y.S. Takeda & Q. Xu. PloS One 10, e0141860 (2015). DOI
  79. Carbonic anhydrase generates a pH gradient in Bombyx mori silk glands. L.J. Domigan, M. Andersson, K.A. Alberti, M. Chesler, Q. Xu, J. Johansson, A. Rising & D.L. Kaplan. Insect Biochem Mol Biol 65, 100-106 (2015). DOI
  80. Neuronal Differentiation of Human Mesenchymal Stem Cells Using Exosomes Derived from Differentiating Neuronal Cells. Y.S. Takeda & Q. Xu. PloS One 10, e0135111 (2015). DOI
  81. Synthetic and nature-derived lipid nanoparticles for neural regeneration. Y.S. Takeda & Q. Xu. Neural Regen Res 10, 689-690 (2015). DOI
  82. Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications. S. Altinoglu, M. Wang & Q. Xu. Nanomedicine (Lond) 10, 643-657 (2015). DOI
  83. Laminar Tendon Composites with Enhanced Mechanical Properties. K.A. Alberti, J.-Y. Sun, W.R. Illeperuma, Z. Suo & Q. Xu. J Mater Sci 50, 2616-2625 (2015). DOI
  84. Fabrication of 2D and 3D constructs from reconstituted decellularized tissue extracellular matrices. Y.S. Takeda & Q. Xu. J Biomed Nanotechnol 10, 3631-3637 (2014). DOI
  85. Emerging therapies targeting intra-organ inflammation in transplantation. Z. Solhjou, H. Athar, Q. Xu & R. Abdi. Am J Transplant 15, 305-311 (2014). DOI
  86. Reactive oxygen species-responsive protein modification and its intracellular delivery for targeted cancer therapy. M. Wang, S. Sun, C.I. Neufeld, B. Perez-Ramirez & Q. Xu. Angew Chem Int Ed Engl 53, 13444-13448 (2014). DOI
  87. Pericellular hydrogel/nanonets inhibit cancer cells. Y. Kuang, J. Shi, J. Li, D. Yuan, K.A. Alberti, Q. Xu & B. Xu. Angew Chem Int Ed Engl 53, 8104-8107 (2014). DOI
  88. Genetically programmable thermoresponsive plasmonic gold/silk-elastin protein core/shell nanoparticles. Y. Lin, X. Xia, M. Wang, Q. Wang, B. An, H. Tao, Q. Xu, F. Omenetto & D.L. Kaplan. Langmuir : the ACS Journal of Surfaces and Colloids 30, 4406-4414 (2014). DOI
  89. High Throughput Screening of Dynamic Silk-Elastin-Like Protein Biomaterials. Q. Wang, X. Xia, W. Huang, Y. Lin, Q. Xu & D.L. Kaplan. Adv Funct Mater 24, 4303-4310 (2014). DOI
  90. Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery. X.-X. Xia, M. Wang, Y. Lin, Q. Xu & D.L. Kaplan. Biomacromolecules 15, 908-914 (2014). DOI
  91. Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles. M. Wang, K. Alberti, A. Varone, D. Pouli, I. Georgakoudi & Q. Xu. Advanced Healthcare Materials 3, 1398-1403 (2014). DOI
  92. Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy. M. Wang, K. Alberti, S. Sun, C.L. Arellano & Q. Xu. Angew Chem Int Ed Engl 53, 2893-2898 (2014). DOI
  93. The behavior of neuronal cells on tendon-derived collagen sheets as potential substrates for nerve regeneration. K.A. Alberti, A.M. Hopkins, M.D. Tang-Schomer, D.L. Kaplan & Q. Xu. Biomaterials 35, 3551-3557 (2014). DOI
  94. DOPE facilitates quaternized lipidoids (QLDs) for in vitro DNA delivery. S. Sun, M. Wang, K.A. Alberti, A. Choy & Q. Xu. Nanomedicine 9, 849-854 (2013). DOI
  95. All electronic approach for high-throughput cell trapping and lysis with electrical impedance monitoring. S.K. Ameri, P.K. Singh, M.R. Dokmeci, A. Khademhosseini, Q. Xu & S.R. Sonkusale. Biosens Bioelectron 54, 462-467 (2013). DOI
  96. Slicing, stacking and rolling: fabrication of nanostructured collagen constructs from tendon sections. K.A. Alberti & Q. Xu. Advanced Healthcare Materials 2, 817-821 (2013). DOI
  97. A combinatorial library of unsaturated lipidoids for efficient intracellular gene delivery. M. Wang, S. Sun, K.A. Alberti & Q. Xu. ACS Synth Biol 1, 403-407 (2012). DOI
  98. Patterning nanoparticles in a three-dimensional matrix using an electric-field-assisted gel transferring technique. X. Dai, S.A. Knupp & Q. Xu. Langmuir : the ACS Journal of Surfaces and Colloids 28, 2960-2964 (2012). DOI
  99. Combinatorial library of lipidoids for in vitro DNA delivery. S. Sun, M. Wang, S.A. Knupp, Y. Soto-Feliciano, X. Hu, D.L. Kaplan, R. Langer, D.G. Anderson & Q. Xu. Bioconjug Chem 23, 135-140 (2012). DOI
  100. Staining and etching: a simple method to fabricate inorganic nanostructures from tissue slices. X. Dai, R. Schalek & Q. Xu. Adv Mater 24, 370-374 (2011). DOI
  101. Microfabrication technologies for oral drug delivery. S. Sant, S.L. Tao, O.Z. Fisher, Q. Xu, N.A. Peppas & A. Khademhosseini. Advanced Drug Delivery Reviews 64, 496-507 (2012). DOI
  102. Nanostructured substrate fabricated by sectioning tendon using a microtome for tissue engineering. X. Dai & Q. Xu. Nanotechnology 22, 494008 (2011). DOI
  103. Tunable self-assembly of genetically engineered silk–elastin-like protein polymers. X.-X. Xia, Q. Xu, X. Hu, G. Qin & D.L. Kaplan. Biomacromolecules 12, 3844-3850 (2011). DOI
  104. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. H. Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M. Ma, S.R. Bogatyrev, Q. Xu, K.A. Whitehead, R. Langer & D.G. Anderson. ACS Nano 4, 625-631 (2010). DOI
  105. An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation. B. Huo, X.L. Lu, K.D. Costa, Q. Xu & X.E. Guo. Cell Calcium 47, 234-241 (2010). DOI
  106. Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules. T.T. Dang, Q. Xu, K.M. Bratlie, E.S. O’Sullivan, X.Y. Chen, R. Langer & D.G. Anderson. Biomaterials 30, 6896-6902 (2009). DOI
  107. Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells. S.W. Cho, M. Goldberg, S.M. Son, Q. Xu, F. Yang, Y. Mei, S. Bogatyrev, R. Langer & D.G. Anderson. Adv Funct Mater 19, 3112-3118 (2009). DOI
  108. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Q. Xu, M. Hashimoto, T.T. Dang, T. Hoare, D.S. Kohane, G.M. Whitesides, R. Langer & D.G. Anderson. Small 5, 1575-1581 (2009). DOI
  109. Nanoskiving: a new method to produce arrays of nanostructures. Q. Xu, R.M. Rioux, M.D. Dickey & G.M. Whitesides. Acc Chem Res 41, 1566-1577 (2008). DOI
  110. Nanoskiving: a novel method for nanofabrication and its applications in nanophotonics. X. Qiaobing & M.W. George. in Proc.SPIE, Vol. 7205 72050P (2009). DOI
  111. Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. S.W. Cho, L. Hartle, S.M. Son, F. Yang, M. Goldberg, Q. Xu, R. Langer & D.G. Anderson. Biochem Biophys Res Commun 376, 158-163 (2008). DOI
  112. Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Y. Mei, C. Cannizzaro, H. Park, Q. Xu, S.R. Bogatyrev, K. Yi, N. Goldman, R. Langer & D.G. Anderson. Small 4, 1600-1604 (2008). DOI
  113. Fluid Flow Induced Calcium Response in Bone Cell Network. B. Huo, X.L. Lu, C.T. Hung, K.D. Costa, Q. Xu, G.M. Whitesides & X.E. Guo. Cell Mol Bioeng 1, 58-66 (2008). DOI
  114. Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. N. Xia, C.K. Thodeti, T.P. Hunt, Q. Xu, M. Ho, G.M. Whitesides, R. Westervelt & D.E. Ingber. Faseb j 22, 1649-1659 (2008). DOI
  115. Fabrication of complex metallic nanostructures by nanoskiving. Q. Xu, R.M. Rioux & G.M. Whitesides. ACS Nano 1, 215-227 (2007). DOI
  116. Fabrication of large-area patterned nanostructures for optical applications by nanoskiving. Q. Xu, J. Bao, R.M. Rioux, R. Perez-Castillejos, F. Capasso & G.M. Whitesides. Nano Lett 7, 2800-2805 (2007). DOI
  117. Intracellular calcium waves in bone cell networks under single cell nanoindentation. X.E. Guo, E. Takai, X. Jiang, Q. Xu, G.M. Whitesides, J.T. Yardley, C.T. Hung, E.M. Chow, T. Hantschel & K.D. Costa. Mol Cell Biomech 3, 95-107 (2006). DOI
  118. Core-shell and segmented polymer-metal composite nanostructures. M. Lahav, E.A. Weiss, Q. Xu & G.M. Whitesides. Nano Lett 6, 2166-2171 (2006). DOI
  119. Fabrication of high-aspect-ratio metallic nanostructures using nanoskiving. Q. Xu, R. Perez-Castillejos, Z. Li & G.M. Whitesides. Nano Lett 6, 2163-2165 (2006). DOI
  120. Surface plasmon resonances of free-standing gold nanowires fabricated by nanoskiving. Q. Xu, J. Bao, F. Capasso & G.M. Whitesides. Angew Chem Int Ed Engl 45, 3631-3635 (2006). DOI
  121. Fabrication of thin, metallic films along the sidewalls of a topographically patterned stamp and their application in charge printing. T. Cao, Q. Xu, A. Winkleman & G.M. Whitesides. Small 1, 1191-1195 (2005). DOI
  122. A general method for patterning gradients of biomolecules on surfaces using microfluidic networks. X. Jiang, Q. Xu, S.K. Dertinger, A.D. Stroock, T.M. Fu & G.M. Whitesides. Anal Chem 77, 2338-2347 (2005). DOI
  123. New approaches to nanofabrication: molding, printing, and other techniques. B.D. Gates, Q. Xu, M. Stewart, D. Ryan, C.G. Willson & G.M. Whitesides. Chem Rev 105, 1171-1196 (2005). DOI
  124. Approaching zero: using fractured crystals in metrology for replica molding. Q. Xu, B.T. Mayers, M. Lahav, D.V. Vezenov & G.M. Whitesides. J Am Chem Soc 127, 854-855 (2004). DOI
  125. Fabrication of Free-Standing Metallic Pyramidal Shells. Q. Xu, I. Tonks, M.J. Fuerstman, J.C. Love & G.M. Whitesides. Nano Letters 4, 2509-2511 (2004). DOI
  126. Shear patterning of microdominos: a new class of procedures for making micro- and nanostructures. B.D. Gates, Q. Xu, V.R. Thalladi, T. Cao, T. Knickerbocker & G.M. Whitesides. Angew Chem Int Ed Engl 43, 2780-2783 (2004). DOI
  127. UNCONVENTIONAL NANOFABRICATION. B.D. Gates, Q. Xu, J.C. Love, D.B. Wolfe & G.M. Whitesides. Annual Review of Materials Research 34, 339-372 (2004). DOI
  128. Fabrication of metal structures with nanometer-scale lateral dimensions by sectioning using a microtome. Q. Xu, B.D. Gates & G.M. Whitesides. J Am Chem Soc 126, 1332-1333 (2004). DOI
  129. Supramolecular research by single molecule force Spectroscopy. W. Zhang, Q. Xu, C. Wang & X. Zhang. Macromolecular Symposia 195, 109-114 (2003). DOI
  130. Oxygen Bridge Inhibits Conformational Transition of 1,4-Linked α-d-Galactose Detected by Single-Molecule Atomic Force Microscopy. Q. Xu, W. Zhang & X. Zhang. Macromolecules 35, 871-876 (2002). DOI
  131. Single-Molecule Force Spectroscopy on Carrageenan by Means of AFM. Q. Xu, S. Zou, W. Zhang & X. Zhang. Macromolecular Rapid Communications 22, 1163-1167 (2001). DOI
  132. Single-Molecule Force Spectroscopy on Bombyx mori Silk Fibroin by Atomic Force Microscopy. W. Zhang, Q. Xu, S. Zou, H. Li, W. Xu, X. Zhang, Z. Shao, M. Kudera & H.E. Gaub. Langmuir 16, 4305-4308 (2000). DOI
keywords:XULAB AT TUFTS BME XULAB AT TUFTS BME